When a person goes missing, every second counts. Based in the heart of one of the country's most colorful law-enforcement cities, the Chicago missing person's unit is the only one in the country that responds to any call within 10 minutes, and they get over 25,000 calls each year. The First 48: Missing Persons follows the elite, passionate, dedicated investigators who handle all missing persons and child abduction cases, and they are specially trained to deal with the nuances of their cases which often involve children. Their commitment to solving these cases is unmatched. The First 48: Missing Persons will follow a core group of detectives as they investigate two high-stakes cases per episode.